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gamble 
  vb 
1 back, bet, game, have a flutter  (informal) lay  or  make a bet, play, punt, put one's shirt on, stake, try one's luck, wager 
2 back, chance, hazard, put one's faith  or  trust in, risk, skate on thin ice, speculate, stake, stick one's neck out  (informal) take a chance, take the plunge, venture 
  n 
3 chance, leap in the dark, lottery, risk, speculation, uncertainty, venture 
4 bet, flutter  (informal) punt, wager 
 
Antonyms  
 
3 certainty, foregone conclusion, safe bet, sure thing