1 alien, beyond one's ken, curious, different, little known, new, novel, out-of-the-way, strange, unaccustomed, uncommon, unknown, unusual
2 (with)
with a stranger to, inexperienced in, unaccustomed to, unacquainted, unconversant, uninformed about, uninitiated in, unpractised in, unskilled at, unversed in
Antonyms
accustomed, acquainted, average, common, commonplace, conversant, everyday, experienced, familiar, knowledgeable, normal, unexceptional, well-known, well-versed